Colóquios da Nano | Violacein as a potential anticancer drug – Prof. Dr. Guillermo R. Castro (UFABC – MaxPlanck Laboratory – Universidad Nacional de Rosario

• Responsável: Pós-graduação em Nanociências e Materiais Avançados
• Câmpus: Evento Virtual
• Local: nano.ufabc.edu.br/coloquios
• Data: 05/07/2022
• Horário: 16:30 às 18:00
• Descrição:

  Palestrante: Profa. Dr. Guillermo R. Castro (UFABC – MaxPlank Laboratory – Universidad Nacional de Rosario)
  Título: Violacein as a potential anticancer drug
  Data: 05/07/2022

  Resumo:
  Graphene-based materials present a high surface area and can present several structural defects or heteroatoms depending on the fabrication method. Such properties facilitate the graphene interaction with biomolecules leading to high electrochemical activity. In this context, we synthesize a high-quality dispersed reduced graphene oxide using Lysozyme as a dispersant (Ly-RGO). In this study, we have investigated the graphite oxidation-reduction fabrication process using X-ray Photoelectron Spectroscopy, X-ray Diffraction, and Raman Spectroscopy. We have used the Ly-RGO to fabricate an electrode on an electrochemical cell in which voltammograms show significant transduction of electrical signals. Finally, cyclic voltammetry and chronoamperometry measurements were performed with human saliva and SARS-CoV-2 RNA samples, to calibrate our biosensor. The results indicate that Ly-RGO has great potential in biosensor devices to pandemics futures.
  References:
  1. RENU SINGH, SEONGKYEOL HONG AND JAESUNG JANG. Label-free Detection of Influenza Viruses using a Reduced Graphene Oxide-based Electrochemical Immunosensor Integrated with a Microfluidic Platform. ScIENTIfIc Reports | 7:42771 | DOI: 10.1038/srep42771, (2017)
  2. J. Zuñiga, T. Pinheiro, M. Rivera, L. Barreto, K.F. Albertin and A. Champi, Synthesis of lysozyme-reduced graphene oxide films for biosensor applications, DOI: doi.org/10.1016/j.diamond.2022.109093. (2022).
  3. https://www.ufabc.edu.br/noticias/pesquisadores-da-ufabc-desenvolvem- dispositivo-portatil-para-detectar-o-sarscov2Violacein (Viol) is a purple biodye produced by Chromobacterium violaceum and other microorganisms that display many beneficial therapeutic properties including anticancer activity. However, Viol is a very

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